Antimicrobial susceptibility of Acinetobacter clinical isolates among ICU Patients in Sana'a City, Yemen

Abstract

1. Drug resistant Acinetobacter strains are important causes of nosocomial infections that are difficult to control and treat. This study aimed to determine the antimicrobial susceptibility patterns of Acinetobacter strains obtained from ICU patients belonging to different age groups at hospitalized patients in Sana'a, Yemen. 88 Acinetobacter isolated were collected from the infected patients admitted to the ICU at a private hospital in Sana’a, Yemen, over one year from March 2020 to April 2021. The records were taken from the microbiology department for hospitalized patients. The results showed that out of 88 samples, 87 (98.8%) were Polymyxin B sensitive isolates and only one sample (1.2%) was resistant. Also, the Colistin sensitive isolates were observed in 100% of culture samples. This study found that 94.3% of culture samples were amoxicillin resistant and 90.9% were ampicillin‎\sulbactam resistant. In addition, Acinetobacter spp. resistance for imipenem, moxifloxacin, meropenem, cefepime, ceftazidime, and ceftriaxone was 95.5, 96.6, 95.5, 97.7, 97.7, and 97.7 %; respectively. The study also revealed the alarming trends of resistance of Acinetobacter strains for the various classes of antimicrobials. It was concluded that improvement of microbiological techniques for earlier and more accurate identification of bacteria is necessary for the selection of appropriate treatments. More careful monitoring for use of broad-spectrum antibiotics should be instituted.