Effect of Pulse Steroid Therapy on Visual Acuity and Fundus Picture in Cases of Vogt Koyanagi Harada Syndrome in Yemen: Case Series Study

Abstract

Vogt-Koyanagi-Harada syndrome (VKHS) is a rare systemic disease with severe bilateral panuveitis associated with cutaneous, neurological, and auditory abnormalities. This study aims to evaluate the effect of pulse steroid therapy on the visual acuity and fundus picture of cases of VKHS presented at Maghrabi Eye Hospital in Yemen. Method: This retrospective case series was followed up for three years between (2007-2010) for three female patients who presented by bilateral hand motion and complained with headache, neck stiffness and difficulty in hearing. Results: After pulse steroid therapy, the best corrected visual was improved with resolution of optic disc swelling and serous retinal detachment detected by optical coherence tomography (OCT). One eye had complication as sunset glow and suprarational fibrosis. Conclusion: VKHS is uncommon disease in Yemen and affects mostly female. Urgent intervention with pulse steroid therapy and systemic corticosteroid and early diagnosis decrease the complications and improve the visual acuity.